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Differentiation into various cell types (neurons, muscle cells, blood cells…).
Self-renewal (infinite multiplication).
They represent a valuable resource for biomedical research and open up major perspectives in:
Stem cells are defined by their potency:
Totipotent stem cell: formed from sperm and egg; gives rise to all body cell types and extra-embryonic tissues (umbilical cord, placenta).
Blastocyst: outer trophoblast → extra-embryonic tissues; inner cell mass → epiblast or primitive endoderm.
Pluripotent stem cells (epiblast): form the fetus and all tissues of the body.
Multipotent stem cells: restricted to certain systems (e.g., haematopoietic stem cells → all blood cell types).
Specialized cells: nullipotent, cannot give rise to other cell types.
ESCs = embryonic stem cells; iPSCs = induced pluripotent stem cells.
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